Efficiency of Ozone therapy as treatment of patients with Diabetic foot.

A study conducted at The University of Havana, Cuba and Ozone research center, Cuba. In collaboration with University of Milan, Italy and Institute of Angiology and Vascular Surgery, Cuba to prove the efficiency of Ozone as treatment of patients with Diabetic foot.

In this study a total of 100 diabetic patients were selected which were all having ulcers of feet and toes. The patients were divided into 2 groups:

1. A group of 49 patients which were treated with antibiotics only.
2. Another group of 51 patients which were treated with Ozone, administered via rectal and topical routes in 20 different sessions.

Parameters considered were:

• Appearance of wound before and after the treatment in both study groups
• Blood glucose levels at the start and end of the study.
• Antioxidant and enzyme levels before and after therapy.

Results:

• The average blood glucose levels in patients of both groups before study were 10.11(+-4.2)mM.
• After giving treatment allocated to both the groups, improvement in average blood glucose levels was seen in 84% patients belonging to the group that received ozone treatment, and only 40% patients of the group receiving antibiotics.
• After the treatment,the blood glucose levels of ozone treated patients were within the normal range I.e. less than 7.8mM while the Blood glucose levels of patients given antibiotics were still higher than the normal range.
• The wounds of the patients that received ozone treatment were healed two times faster as compared to the wounds of the patients which were given antibiotics.
• The duration of hospitalization was also significantly reduced in the patients of ozone group as compared to antibiotic group.
• Oxidant levels, which were approximately 142µM before the treatment were brought back to normal i.e. 103.7(+-17.7)µM in Ozone group, while no decrease in oxidant levels were seen in antibiotic group.
• Other enzyme parameters were also improved significantly in ozone treated patients as compared to patients treated with antibiotics

Conclusion:

The study proved that diabetic patients with foot ulcers which were treated with ozone not only had 25% less expenditure on treatment but also showed a very significant and quick improvement of sign and symptom and biochemical parameters as compared to patients that received only antibiotics.